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wxGlade is a GUI designer written in Python with the popular GUI toolkit wxPython, that helps you create wxWidgets/wxPython user interfaces. At the moment it can generate Python, C++ and XRC (wxWidgets' XML resources) code.
As you can guess by the name, its model is Glade, the famous GTK+/GNOME GUI builder, with which wxGlade shares the philosophy and the look & feel (but not a line of code).